Description
The fourth-generation HIV test is the recommended test and can detect HIV as early as 14 days following transmission by detecting HIV p24 Ag. HIV RNA viral load can be performed if an acute infection is suspected (less than 2 weeks after possible exposure to HIV).
HIV 4+1 kits are used to detect HIV-1 and HIV-2 in human serum or plasma:
- Screening:Â HIV 4+1 kits can be used to screen blood donors or other people at risk of HIV infection.
- Clinical diagnosis:Â HIV 4+1 kits can be used for clinical diagnostic testing.Â
HIV 4+1 kits are immunoassays that detect HIV by looking for:
- p24 antigen:Â Detectable as early as 14 days after exposure
- Antibodies:Â Formed against HIV-1 and HIV-2Â
HIV 4+1 kits are an improvement over earlier generation tests because they can detect HIV earlier and differentiate between HIV-1 and HIV-2.Â
A positive HIV 4+1 test result needs to be confirmed with an HIV-1/2 antibody differentiation immunoassay.
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