Description
Troponin I (TnI) is part of troponin complex, which together with tropomyosin, forms the main component that regulates the Ca+2 –sensitive ATP-ase activity of actomyosin is striated muscle (skeletal and cardiac). The troponin complex consists of three subunit has a distinct function with TnC as the site of Ca+2 binding, TnT the tropomyosin binding, and Tnl as the inhibitory subunit. Different isoforms of Tnl exists in the skeletal and cardiac muscles (sTnl and cTnl, respectively) with distinct immunologic epitopesthat allow the production ofncardiac-specific Tnl antibodies. The cardiac marker,troponin I has been established as useful tools in the diagnosis of acute myocardial infraction (AMI). Troponin I is found in blood at elevated concentrations approximately 4-6 hours after the onset of chest pain and peak at 12-24 hours. Troponin I levels remain elevated for up to 14 days. The use if this markeris an aid in the diagnosis of AMI after myocardial function.
Precautions:
- For in vitro diagnostics use only.
- Do not use beyond the expiration date.
- Use separate syringe or clean pipette tips for different specimens. Do not pipette by mouth.
- Do not smoke, eat or drink in areas in which specimens or kits are handled.
- Wear disposables gloves while handling specimens and running the tests, and thoroughly wash hands afterwards.
- All patient samples should be handled as if they are capable of transmitting diseases. Observe established good laboratory procedures for proper disposal of specimens, used pipette tips or syringes, and used test devices.
- The test device should remain in its sealed pouch until ready for use. Humidity and temperature can adversely affect results.
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